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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3-L1Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionRT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3-L1cells with different gene expression levels, including insulin receptor substrate-1(IRS-1), phosphatidylinositolThe glucose uptake decreased with the increase in gene expression in 3T3-L1 cells, which was independent

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isa cell surface receptor expressed on monocytes/macrophages and neutrophils.TREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway.Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluidsand well-known biomarker for infectious diseases. sTREM-1 level can be potentially used for the early

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: (HIF-1α) and transferrin receptor (TfR).Expressions of epidermal growth factor receptor (EGFR), phosphor-EGF-R and TfR after UVB irradiationThe DEC1 (-/-) Ha-Cat cells did not increase their TfR and HIF-1α expressions following UVB irradiationIn contrast, DEC1 (+/+) HaCat cells strongly enhanced TfR and HIF-1?We conclude that UVB induces TfR and HIF-1αexpressions via EGFR/PI3K/AKT/DEC1 signaling pathway.
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Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: PAR-1 and PAR-2 are widely expressed in a variety of cells and are found to be involved in many physiologicalHowever, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.PAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: receptor (AT1a) on blood pressure and cardiac hypertrophy of rats with renovascular hypertension.Two RNAi plasmids, pAT1a-shRNA1 and pAT1a-shRNA2 each carrying a U6 promoter and an AT1a-specific shRNA-codingCompared with the control group, pAT1a-shRNA1 and pAT1a-shRNA2 groups had lowered expression of AT1 receptorreceptor in valsartan and the control groups ( > 0.05).We conclude that RNAi targeting AT1a receptor inhibits the development of renovascular hypertension and

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Effect of streambed substrate on macroinvertebrate biodiversity

DUAN Xuehua, WANG Zhaoyin, TIAN Shimin

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 1,   Pages 122-128 doi: 10.1007/s11783-008-0023-y

Abstract: Numerous studies have shown that substrate is the primary physical environmental variable affecting theThe aim of this work is to study the effects of the characteristics of streambed substrate, such as grainassemblage is significantly affected by the grain size, porosity and interstitial dimension of the substrate

Keywords： Substrata     physical environmental     indicator     ecology     substrate    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: influence of β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptortype 1 (AT1R) in hepatic stellate cells (HSCs)The protein expression of AT1R was detected by western blot.( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1RThe expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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Aerobic granular sludge formation based on substrate availability: Effects of flow pattern and fermentation

Quan Yuan, Hui Gong, Hao Xi, Kaijun Wang

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1226-0

Abstract: Penetration depth and substrate characters affect AGS formation and performance.The relationship between substrate gradient and particle size affects AGS stability.and plug-flow) and fermentation pretreatment on aerobic granular sludge (AGS) formation with various substrateavailability levels were investigated by running four identical laboratory-scale sequencing batch reactors (R1–R1 achieved faster granulation with a fast influent fill step followed by a modified anaerobic mixed-flow

Keywords： Anaerobic plug-flow feeding mode     Anaerobic mixed-flow mode     Fermentation pretreatment     Substrate gradient    

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V-shaped substrate for surface and volume enhanced Raman spectroscopic analysis of microplastics

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 11, doi: 10.1007/s11783-022-1578-8

Abstract:

● V-shaped substrate was obtained for SERS analysis of microplastics(diameter ≈ 1 μm).

Keywords： SERS     V-shaped     AAO     Microplastic     Atmospheric aerosol    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract: cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Elastic modulus and thermal stress in coating during heat cycling with different substrate shapes

Daniel GAONA,Alfredo VALAREZO

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 3,   Pages 294-300 doi: 10.1007/s11465-015-0351-0

Abstract: k) of a one-side coated long plate, namely, a one-dimensional (1D) deformation model.The aim of this research is to design an experimental setup that proves whether a 1D deformation modelSeveral samples fabricated with aluminum as the substrate and 100MXC nanowire (Fe and Cr alloy) as theThe correspondence between the experimental and simulated results for the 1D and 2D specimens revealsAn example of a turbine-blade-shaped substrate is presented to validate the approach.

Keywords： in-plane     Young’s modulus     curvature temperature     thermal stress     coating    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitorsoutput, and consider the problems of signaling pathway redundancy and how the activation of different receptor

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Low-cost high-order-mode cavity backed slot array antenna using empty substrate integrated waveguide

Zihang Qi, Xiuping Li, Hua Zhu,qizihang@bupt.edu.cn,xpli@bupt.edu.cn,judy-cool@163.com

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 4,   Pages 609-614 doi: 10.1631/FITEE.2000503

Abstract: Empty substrate-integrated waveguide is used to avoid high dielectric loss.
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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been

Keywords： Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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Title Author Date Type Operation

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Effect of streambed substrate on macroinvertebrate biodiversity

DUAN Xuehua, WANG Zhaoyin, TIAN Shimin

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

Aerobic granular sludge formation based on substrate availability: Effects of flow pattern and fermentation

Quan Yuan, Hui Gong, Hao Xi, Kaijun Wang

Journal Article

V-shaped substrate for surface and volume enhanced Raman spectroscopic analysis of microplastics

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Elastic modulus and thermal stress in coating during heat cycling with different substrate shapes

Daniel GAONA,Alfredo VALAREZO

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Low-cost high-order-mode cavity backed slot array antenna using empty substrate integrated waveguide

Zihang Qi, Xiuping Li, Hua Zhu,qizihang@bupt.edu.cn,xpli@bupt.edu.cn,judy-cool@163.com

Journal Article

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article